Fusion construct of CR17 from LRP-1 and ApoE residues 130-149
Structure of the minimal interface between ApoE and LRP.
Fusion of LRP UNP residues 2770-2817 and Apo-E UNP residues 147-167
LRP, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, Low-density lipoprotein receptor-related protein 1 85 kDa subunit, LRP-85, Low-density lipoprotein receptor-related protein 1 515 kDa subunit, LRP-515, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRPICD
structures with the least restraint violations
DGSA-distance geometry simulated annealing
20 mM [U-99% 2H] HEPES-1, 50 mM sodium chloride-2, 3 mM sodium azide-3, 5 mM CALCIUM ION-4, 0.8 mM [U-99% 13C; U-99% 15N] entity_1-5, 90% H2O/10% D2O
20 mM [U-99% 2H] HEPES-6, 50 mM sodium chloride-7, 3 mM sodium azide-8, 5 mM CALCIUM ION-9, 0.8 mM [U-99% 13C; U-99% 15N] entity_1-10, 100% D2O
20 mM [U-99% 2H] HEPES-11, 50 mM sodium chloride-12, 3 mM sodium azide-13, 5 mM CALCIUM ION-14, 0.8 mM [U-99% 15N] entity_1-15, 90% H2O/10% D2O
Brunger, Adams, Clore, Gros, Nilges and Read
Prolow-density lipoprotein receptor-related protein 1
LRP, ApoE, Lipoprotein receptor, ligand binding module, complement repeat, Calcium, Cell membrane, Coated pit, Cytoplasm, Developmental protein, Disulfide bond, EGF-like domain, Endocytosis, Glycoprotein, Membrane, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Receptor, Transmembrane, Protein binding, METAL BINDING PROTEIN