The Solution Structure of a Conformationally Restricted Fully Active Derivative of the Human Relaxin-like Factor (RLF)
Solution structure of a conformationally restricted fully active derivative of the human relaxin-like factor
Leydig insulin-like peptide, Ley-I-L, Relaxin-like factor, RLF
cross-linked derivative determine under the same experimental conditions
This sequence occurs naturally in humans.
torsion angle dynamics, simulated annealing
1.2 mM RLF_crosslinked; sodium acetate, 92% H2O/8% D2O
1.2 mM RLF_crosslinked; sodium acetate, 100% D2O
Brunger, Adams, Clore, Gros, Nilges and Read
Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax
protein, cross-link, isopeptide, Cleavage on pair of basic residues, Disease mutation, Hormone, Polymorphism, Secreted