HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE

The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis.

PLP FORMING INTERNAL ALDIMINE WITH LYS265

MTEAAAQPHALPADAPDIAPERDLLSKFDGLIAERQKLLDSGVTDPFAIVMEQVKSPTEAVIRGKDTILLGTYNYMGMTF
DPDVIAAGKEALEKFGSGTNGSRMLNGTFHDHMEVEQALRDFYGTTGAIVFSTGYMANLGIISTLAGKGEYVILDADSHA
SIYDGCQQGNAEIVRFRHNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKKHGAMVLVDEAHSMGFFG
PNGRGVYEAQGLEGQIDFVVGTFSKSVGTVGGFVVSNHPKFEAVRLACRPYIFTASLPPSVVATATTSIRKLMTAHEKRE
RLWSNARALHGGLKAMGFRLGTETCDSAIVAVMLEDQEQAAMMWQALLDGGLYVNMARPPATPAGTFLLRCSICAEHTPA
QIQTVLGMFQAAGRAVGVIGLE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

SERINE PALMITOYLTRANSFERASE (E.C.2.3.1.50)

SPT, PLP, SSPF, TRANSFERASE, SPHINGOLIPID, PYRIDOXAL PHOSPHATE, SERINE PALMITOYL TRANSFERASE