Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate

Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues.

5', 3'-NUCLEOTIDASE, MITOCHONDRIAL, MITOCHONDRIAL DEOXYRIBONUCLEOTIDASE, DEOXY-5'-NUCLEOTIDASE 2, DNT-2

GGRALRVLVNMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGA
VEAVKEMASLQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEH
VLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC

20% PEG8000, 0.050 M POTASSIUM DIHYDROGEN PHOSPHATE, PH 4.5, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 293K

CRYSTAL STRUCTURE ANALYSIS OF DEOXYRIBONUCLEOTIDASE

CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH THE INHIBITOR DPB-T

CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH THE INHIBITOR PMCP-U

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH DEOXYRIBOURIDINE 5'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH URIDINE 2'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH THYMIDINE 3'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH THYMIDINE 5'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH URIDINE 5'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH DEOXYRIBOGUANOSINE5'-MONOPHOSPHATE

STRUCTURE OF THE D41N VARIANT OF THE HUMAN MITOCHONDRIALDEOXYRIBONUCLEOTIDASE IN COMPLEX WITH 2',3'-DIDEOXY-2',3-DIDEHYDROTHYMIDINE 5'-MONOPHOSPHATE (D4T-MP)

CRYSTAL STRUCTURE OF D41N VARIANT OF HUMAN MITOCHONDRIAL 5'(3')-DEOXYRIBONUCLEOTIDASE (MDN ) IN COMPLEX WITH 5-BROMOVINYLDEOXYURIDINE 5 '-MONOPHOSPHATE

ENGINEERED RESIDUE IN CHAIN A, ASP 41 TO ASN

MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRAR
FPDQPFIA

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

TRANSIT PEPTIDE, NUCLEOTIDE-BINDING, MITOCHONDRIAL, METAL-BINDING, ALFA BETA FOLD, NUCLEOTIDE- BINDING, NUCLEOTIDE METABOLISM, HYDROLASE, MAGNESIUM, MITOCHONDRION