Tryptophan Synthase in complex with GP, alpha-D,L-glycerol-phosphate, Cs, pH6.5 - alpha aminoacrylate form - (GP)E(A-A)

2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID

Allosteric Regulation of Substrate Channeling in Tryptophan Synthase: Modulation of the L-Serine Reaction in Stage I of the Beta-Reaction by Alpha-Site Ligands.

MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTLIDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQ
CFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQVGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADD
DLLRQVASYGRGYTYLLSRSGVTGAENRGALPLHHLIEKLKEYHAAPALQGFGISSPEQVSAAVRAGAAGAISGSAIVKI
IEKNLASPKQMLAELRSFVSAMKAASRA

TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEFQAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLL
HGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASALASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHS
GSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIVREFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMF
ADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFGMKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGR
ADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKMMREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGEI

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHAD60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA =2=BETA=2= COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE

TRYPTOPHAN SYNTHASE FROM SALMONELLA TYPHIMURIUM

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2- AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID

CRYSTAL STRUCTURE OF BETAA169L/BETAC170W DOUBLE MUTANT OFTRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUORO-INDOLE-PROPANOLPHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]ASPARTIC ACID

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]GLYCINE ACID

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH N-[1H-INDOL-3-YL- ACETYL]VALINE ACID

CRYSTAL STRUCTURE OF THE BETA-SER178PRO MUTANT OFTRYPTOPHAN SYNTHASE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM

CRYSTAL STRUCTURE OF THE TRYPTOPHAN SYNTHASE BETA-SER178PROMUTANT COMPLEXED WITH D,L- ALPHA-GLYCEROL-3-PHOSPHATE

CRYSTAL STRUCTURE OF THE TRYPTOPHAN SYNTHASE BETA-SER178PROMUTANT COMPLEXED WITH N-[1H- INDOL-3-YL-ACETYL]GLYCINE ACID

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH INDOLE GLYCEROLPHOSPHATE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH INDOLE PROPANOLPHOSPHATE

CRYSTAL STRUCTURE OF ALPHAT183V MUTANT OF TRYPTOPHANSYNTHASE FROM SALMONELLA TYPHIMURIUM WITH L-SER BOUND TOTHE BETA SITE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH L-SERINE

CRYSTAL STRUCTURE OF TRYPTOPHAN SYNTHASE FROM SALMONELLATYPHIMURIUM

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH INDOLE PROPANOL PHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH INDOLE GLYCEROL PHOSPHATE

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASECOMPLEXED WITH 1-[(2-HYDROXYLPHENYL) AMINO]3-GLYCEROLPHOSPHATE

TRYPTOPHAN SYNTHASE IN THE PRESENCE OF CESIUM, ROOM TEMPERATURE

TRYPTOPHAN SYNTHASE WITH A MUTATION OF LYS 87 ->THR IN THE B SUBUNIT AND IN THE PRESENCE OF LIGAND L-SERINE

WILDTYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH GLYCEROL PHOSPHATE

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZOYL)-2-AMINO-1- ETHYLPHOSPHATE (F6) - LOWF6 COMPLEX

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZOYL)-2-AMINO-1- ETHYLPHOSPHATE (F6) - HIGHF6 COMPLEX

TRYPTOPHAN SYNTHASE IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1- ETHYLPHOSPHATE (F9)

TRYPTOPHAN SYNTHASE IN COMPLEX WITH D- GLYCERALDEHYDE 3-PHOSPHATE (G3P)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH N-(4'- TRIFLUOROMETHOXYBENZENESULFONYL)-2-AMINO-1- ETHYLPHOSPHATE (F9)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH N-(4'-TRIFLUOROMETHOXYBENZOYL )-2-AMINO-1-ETHYLPHOSPHATE (F6)

TRYPTOPHAN SYNTHASE (EXTERNAL ALDIMINE STATE) IN COMPLEX WITH (NAPHTHALENE-2'-SULFONYL)-2 -AMINO-1-ETHYLPHOSPHATE (F19)

CRYSTAL STRUCTURES OF MUTANT (BETAK87T) TRYPTOPHAN SYNTHASE ALPHA=2 BETA=2= COMPLEX WITH LIGANDS BOUND TO THE ACTIVE SITES OF THE ALPHA AND BETA SUBUNITS REVEAL LIGAND-INDUCED CONFORMATIONAL CHANGES

CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE

TRYPTOPHAN SYNTHASE Q114N MUTANT IN COMPLEX WITH COMPOUND II

AROMATIC AMINO ACID BIOSYNTHESIS, TRYPTOPHAN BIOSYNTHESIS, CRBON- OXYGEN LYASE, AMINO-ACID BIOSYNTHESIS, LYASE, ALLOSTERIC ENZYME, PYRIDOXAL PHOSPHATE, SYNTHASE