Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta

Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery.

Receptor-type tyrosine-protein phosphatase beta

Protein-tyrosine phosphatase beta, R-PTP-beta

SDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQ
DSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPT
VVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQ

21% PEG 8000, 220 mM MgCl2, 1% BME, 0.1% BOG, 5mM DTT, VAPOR DIFFUSION, HANGING DROP, temperature 298K

Engineered protein tyrosine phosphatase beta catalytic domain

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

protein tyrosine phosphatase, WPD-loop, sulfamic acid, phosphatase, inhibitor, drug design, HYDROLASE