Crystal structure of Cys318Ala mutant of human mitochondrial branched chain aminotransferase

4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

Human Mitochondrial Branched Chain Aminotransferase Isozyme: STRUCTURAL ROLE OF THE CXXC CENTER IN CATALYSIS.

Branched-chain-amino-acid aminotransferase, mitochondrial

BCATm, Placental protein 18, PP18, Mitochondrial Branched Chain Aminotransferase

ASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKA
FKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPRR
ALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGT
MNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVAPV
HRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV

PEG1500, DTT, HEPES pH7.0, VAPOR DIFFUSION, HANGING DROP, temperature 294K

Crystallographic structure of human branched chain amino acid aminotransferase (mitochondrial) complexed with pyridoxal-5'-phosphate at 1.95 angstroms (orthorhombic form).

Crystal structure of human branched chain amino acid aminotransferase (mitochondrial) complexed with pyridoxal- 5'-phosphate at 2.5 angstroms (monoclinic form).

Human branched chain amino acid aminotransferase (mitochondrial): Three dimensional structure of enzyme inactivated by tris bound to the pyridoxal-5'-phosphate on one end and active site Lys202 NZ on the other.

Human branched chain amino acid aminotransferase: Three dimensional structure of the enzyme in its pyridoxamine phosphate form.

Human branched chain amino acid aminotransferase (mitochondrial): Three dimensional structure of enzyme in its ketimine form with the substrate L-isoleucine.

X-ray crystal structure of human mitochondrial branched chain aminotransferase (BCATm) complexed with gabapentin.

Crystal Structure of Cys315Ala-Cys318Ala Mutant of Human Mitochondrial Branched Chain Aminotransferase.

Crystal Structure of Cys315Ala mutant of human mitochondrial branched chain aminotransferase complexed with its substrate mimic, N-methyl leucine.

Crystal structure of Cys315Ala mutant of human mitochondrial branched chain aminotransferase.

X-ray crystal structure of oxidized human mitochondrial branched chain aminotransferase (hBCATm).

D-aminoacid aminotransferase-like PLP-dependent enzymes, TRANSFERASE

ASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKA
FKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTR
ALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGT
MNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPV
HRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV