AmpC beta-lactamase in complex with 4-Amino-3-hydroxybenzoic acid

Deconstructing fragment-based inhibitor discovery

APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEI
KLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAV
KPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDI
NEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFG
SYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ

1.8M potassium phosphate, pH 8.7, VAPOR DIFFUSION, HANGING DROP, temperature 294K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

AmpC fragment-based drug design beta-lactamase, HYDROLASE