3D structure of inactive human Rab11b GTPase

The crystal structure of the small GTPase Rab11b reveals critical differences relative to the Rab11a isoform.

MYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRRITSAYYRGAVG
ALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFK
NILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTD

Reservoir solution: 0.1M Tris-HCl pH8.8, 30% PEG 4000
Protein sample: 30 mg/ml Rab11b-GDP, 10mM Tris-HCl pH7.4, 0.1mM Mg Chloride , VAPOR DIFFUSION, HANGING DROP, temperature 298K

3D structure of active human Rab11b GTPase

Rab11b GTPase, vesicle transport, HYDROLASE

YDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRRITSAYYRGAVGA
LLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKN
ILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTD