Crystal structure of humanized KR127 FAB

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism

DIQMTQTPLSLSVTPGQPASISCKSSQSLLYSNGKTYLNWLLQKPGQSPKRLIYLVSKLDSGVPDRFSGSGSGTDFTLKI
SRVEAEDVGVYYCVQGTHFPQTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

QVQLVQSGAEVVKPGASVKVSCKASGYAFSSSWMNWVRQAPGQGLEWIGRIYPGDGDTNYAQKFQGKATLTADKSTSTAY
MELSSLRSEDTAVYFCAREYDEAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA
LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

17% PEG 4000, 10mM Hepes-NaOH, 0.2M ammonium sulfate, pH 7.50, VAPOR DIFFUSION, HANGING DROP, temperature 288K

the same protein in complex with PRES1 peptide epitope

A SEQUENCE DATABASE REFERENCE FOR THIS PROTEIN DOES
NOT CURRENTLY EXIST.
THE SEQUENCES ARE SHOWN IN THE PAPER(FIGURE 1):
HONG, H.J. ET AL., VIROLOGY 318, 134-141 (2004)

HEPATITIS B VIRUS, HUMANIZED ANTIBODY, MONOCLONAL ANTIBODY, NEUTRALIZATION, PRES1, IMMUNE SYSTEM