Crystal Structure of LILRB2(LIR2/ILT4/CD85d) complexed with HLA-G

Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)

HLA class I histocompatibility antigen, alpha chain G

Leukocyte immunoglobulin-like receptor subfamily B member 2

Leukocyte immunoglobulin-like receptor 2, LIR-2, Immunoglobulin- like transcript 4, ILT-4, Monocyte/macrophage immunoglobulin-like receptor 10, MIR-10, CD85d antigen

MGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSASPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQ
TLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQRRAY
LEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDG
TFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQ

MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA
CRVNHVTLSQPKIVKWDRDM

GTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRLYREKKSASWITRIRPELVKNGQFRIPSITWEHTGRYGCQYYSR
ARWSELSDPLVLVMTGAYPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEDEHPQCLNSQPHARGSSRAIFSV
GPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVP

0.1M Tris-HCl pH8.0, 45% PEG400, VAPOR DIFFUSION, HANGING DROP, temperature 293K

The interaction between HLA-G (the molecule composed of chain A/B/C) and LILRB2 (chain D) is a biological unit.