Solution structure of Dermaseptin antimicrobial peptide truncated, mutated analog, K4-S4(1-13)a
Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative k4-s4-(1-13)
Acylated derivative of the Dermaseptin analog, NC12-K4-S4(1-13)a.
This is a truncated, mutated, amidated sequence that occurs naturally in frog skin secretions.
This structure was determined using standard 2D homonuclear techniques.
structures with the lowest energy, structures with the least restraint violations
The structures are based on 250 restraints comprising: 83 intraresidual; 78 i,i+1; 34 i,i+2; 37 i,i+3; 18 long range
Peptide concentration 2.2mM natural abundance; 20:1 molar ratio of DPC-d38 to peptide; 10% phosphate buffer; 10% D2O; 0.02% NaN3
10% phosphate buffer; 10% D2O; 0.02% NaN3 in triple distilled water
Laskowski, Rullmannn, MacArthur, Kaptein, Thornton