Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins

MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETY
KVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTES
AKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGE
EAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTT
YFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGFMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV

HUMAN MONOAMINE OXIDASE TYPE B (TRUNCATED)

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH 1,4-DIPHENYL-2-BUTENE

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH ISATIN

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH TRANYLCYPROMINE

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH LAURYLDIMETHYLAMINE-N-OXIDE (LDAO)

CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-PROPARGYL-1(R)-AMINOINDAN (RASAGILINE)

CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-PROPARGYL-1(S)-AMINOINDAN

CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH N-METHYL-N-PROPARGYL-1(R)-AMINOINDAN

CRYSTAL STRUCTURE OF MAOB IN COMPLEX WITH 6-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH FARNESOL

HUMAN MONOAMINE OXIDASE B: I199F MUTANT IN COMPLEX WITH RASAGILINE

HUMAN MONOAMINE OXIDASE B: I199F MUTANT IN COMPLEX WITH ISATIN

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH DEPRENYL

ENGINEERED RESIDUE IN CHAIN A, TYR 434 TO PHE ENGINEERED RESIDUE IN CHAIN B, TYR 434 TO PHE

THE MUTATED RESIDUE IS NUMBERED 435 IN THE COORDINATE RECORDS BELOW.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.

OXIDOREDUCTASE, ENANTIOSELECTIVITY, FAD, FLAVIN, FLAVOPROTEIN, HUMAN MONOAMINE OXIDASE, INHIBITOR BINDING, MITOCHONDRION, RASAGILINE, TRANSMEMBRANE, PARKINSON, ACETYLATION