Structure-based design of Protein Tyrosine Phosphatase-1B Inhibitors

PROTEIN-TYROSINE PHOSPHATASE NON-RECEPTOR TYPE 1

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRS
YILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLEL
ENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPH
N

PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL- PHOSPHATEINTERMEDIATE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH TWO BIS(PARA- PHOSPHOPHENYL)METHANE (BPPM)MOLECULES

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 6-(OXALYL-AMINO )-1H-INDOLE-5-CARBOXYLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 3-(OXALYL-AMINO )-NAPHTHALENE-2-CARBOXLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO )-BENZOIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2 -(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2, 3-C]PYRAN-3-CARBOXYLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO- 4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3- CARBOXYLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 2-(OXALYL-AMINO )-4,5,6,7-TETRAHYDRO-THIENO[2,3-C] PYRIDINE-3-CARBOXYLIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH 5-IODO-2-( OXALYL-AMINO)-BENZOIC ACID

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH ACETYL-D-A-D- BPA-PTYR-L-I-P-Q-Q-G

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH ACETYL-E-L-E- F-PTYR-M-D-Y-E-NH2

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A TRI- PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR )RK) FROM THE INSULIN RECEPTOR KINASE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A MONO- PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH A BIS- PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL ) FROM THE INSULIN RECEPTOR KINASE

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326

RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITYOF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA

CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S ) MUTANT

HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836

HUMAN TYROSINE PHOSPHATASE 1B COMPLEXED WITH AN INHIBITOR

CRYSTAL STRUCTURE OF PTP1B COMPLEXED WITH 7 -(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3- YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO- 5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID

STRUCTURE OF PTP1B IN COMPLEX WITH A PEPTIDICBISPHOSPHONATE INHIBITOR

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 12 USING A LINKED- FRAGMENT STRATEGY

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 23 USING A LINKED- FRAGMENT STRATEGY

POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITORCOMPOUND 5 USING A LINKED- FRAGMENT STRATEGY

PTP1B R47C MODIFIED AT C47 WITH N-[4-(2 -{2-[3-(2-BROMO-ACETYLAMINO)-PROPIONYLAMINO ]-3-HYDROXY-PROPIONYLAMINO}-ETHYL)-PHENYL]- OXALAMIC ACID

CRYSTAL STRUCTURE OF THE PTP1B COMPLEXED WITH SP7343-SP7964,A PTYR MIMETIC

POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINEPHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE,COMPLEXED WITH COMPOUND 19.

PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO A SULFENYL-AMIDE BOND

PTP1B WITH THE CATALYTIC CYSTEINE OXIDIZED TO SULFONIC ACID

OXIDATION STATE OF PROTEIN TYROSINE PHOSPHATASE 1B

OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B,COMPOUND 17

OXALYL-ARYL-AMINO BENZOIC ACID INHIBITORS OF PTP1B,COMPOUND 8B

CRYSTAL STRUCTURE OF THE C215D MUTANT OF PROTEIN TYROSINEPHOSPHATASE 1B

NON-CARBOXYLIC ACID-CONTAINING INHIBITOR OF PTP1B TARGETINGTHE SECOND PHOSPHOTYROSINE SITE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE- CONTAINING TETRA-PEPTIDE(AC-DEPYL-NH2)

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE- CONTAINING HEXA-PEPTIDE(DADEPYL-NH2)

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH PHOSPHOTYROSINE

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1BCOMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B WITHPOTENT AND SELECTIVE BIDENTATE INHIBITOR COMPOUND 2

DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1BINHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATEHEAD ON THE FIRST SITE

A HIGHLY EFFICIENT APPROACH TO A SELECTIVE AND CELL ACTIVEPTP1B INHIBITORS

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 2

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 3

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 4

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 6

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 9

THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEXWITH COMPOUND 11

MONOACID-BASED, CELL PERMEABLE, SELECTIVE INHIBITORS OFPROTEIN TYROSINE PHOSPHATASE 1B

1.95 A STRUCTURE OF APO PROTEIN TYROSINE PHOSPHATASE 1B

ALLOSTERIC INHIBITION OF PROTEIN TYROSINE PHOSPHATASE 1B

PROTEIN TYROSINE PHOSPHATASE 1B WITH ACTIVE SITE INHIBITOR

PTP1B COMPLEXED WITH ISOXAZOLE CARBOXYLIC ACID

PROTEIN TYROSINE PHOSPHATASE, 1, 2, 5-THIADIAZOLIDIN-3-ONE-1, 1-DIOXIDE TEMPLATE, HYDROLASE