Structural basis for the inhibition of activin signalling by follistatin

Activin beta-A chain, Erythroid differentiation protein, EDF

GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSC
CVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Ammonium sulphate, PEG300, Na-Hepes, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

The biological unit is a homodimer as found in the asymmetric unit

homodimer, cystine knot, disulfide linked, HORMONE-GROWTH FACTOR COMPLEX