Crystal structure (I) of Nova-1 KH1/KH2 domain tandem with 25 nt RNA hairpin

Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.

Neuro-oncological ventral antigen 1,Ventral neuron-specific protein 1

PLGSQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKIREMP
QNVAKTEPVSILQPQTTVNPDRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLSQKPDGINLQNRVVTVSGEPE
QNRKAVELIIQKIQEDPQ

PEG 4000, isopropanole, sodium citrate, potassium chloride, magnesium chloride, pH 5.6, VAPOR DIFFUSION, temperature 293K

Crystal structure (II) of KH1/KH2 domain tandem with 25 nt RNA hairpin.

Nova-2 KH3 domain from PDB ENTRY 1EC6, and idealised 5 bp A-RNA

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

PROTEIN-RNA COMPLEX, RNA-binding protein-RNA COMPLEX

QYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTIEALNAVHGFIAEKIREMPQNVA
KTEPVSILQPQTTVNPDRIKQTLPSSPTTTKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAIMEQSGAWVQLS
QKPDGINLQERVVTVSGEPEQNRKAVELIIQKIQEDPQ