Crystal Structure of Imidazoleglycerol-phosphate Dehydratase from Staphylococcus aureus subsp. aureus N315

Midwest Center for Structural Genomics (MCSG)

HHHHHHSSGVDLGTENLYFQSNIGSGSNA(MSE)IYQKQRNTAETQLNISISDDQSPSHINTGVGFLNH(MSE)LTLFTF
HSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLE(MSE)IKDKKHFVRYGT(MSE)YIP(MSE)DETLARVVVDISGRP
YLSFNASLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVI
E

HHHHHHSSGVDLGTENLYFQSNIGSGSNAMIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNI
EAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNASLSKEKVGTFDTEL
VEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE

PEG400, sodium citrate, Tris pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 277K

Imidazoleglycerol-phosphate dehydratase (E.C.4.2.1.19)

beta-alpha-beta sandwich, duplication of a half-domain, imidazoleglycerol-phosphate dehydratase (IGPD), Structural Genomics, PSI, Protein Structure Initiative, Midwest Center for Structural Genomics, MCSG, LYASE

MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMI
KDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNASLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHE
IEAIFKAFSRALGIALTATDDQRVPSSKGVIE