Mineralocorticoid Receptor S810L Mutant with Bound Progesterone

A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor

GSAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPG
FKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEY
TIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRES
HALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK

0.1m Hepes pH7.5, 0.9M Li2SO4, 2% PEG 2KMME, vapor diffusion, hanging drop, temperature 298K

BIOMOLECULE: 1
THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC
ASYMMETRIC UNIT WHICH CONSISTS OF 2 CHAIN(S). THE
BIOLOGICAL UNIT IS A DIMER, BUT THE DIMER IN THE CRYSTAL IS
IRRELEVANT BIOLOGICALLY. THE BIOLOGICAL DIMER IS CURRENTLY
UNKNOWN.

Mineralocorticoid receptor, MR, Nuclear Receptor, Steroid Receptor, Progesterone, Hypertension, TRANSCRIPTION

APAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFK
NLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTI
MKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHA
LKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK