PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase.

SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVT
IDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK
MFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFR
SYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGG
VAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCS

PEG 6000, Tris chloride, magnesium chloride, DTT, BME, AMP-PNP., pH 7.4, VAPOR DIFFUSION, temperature 277K

HETEROGEN
ANP 901 and MG 903 are associated with protein chain A
ANP 902 and MG 904 are associated with protein chain B

The biological unit is the dimer in the asymmetric unit.