Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033

Identification of potent and selective MMP-13 inhibitors

YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSG
LLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQ
SLYGP

20% PEG3350, 0.15M Ammonium Sulfate, 0.1M tris pH 8.5, pH 8.50, VAPOR DIFFUSION, HANGING DROP, temperature 291K

HETEROGEN
The Ca atoms 560, 561, 562 are associated with Chain A,
563, 564, 565 with chain B, 566, 567, 568 with chain C and
569, 570 and 571 with chain D.

MMPs, METALLOPROTEASE, HYDROLASE, MMP-13, COLLAGENASE, ZINC CHELATOR, hydroxamate, hydrophobic S1', P1' group