Structure of ellipticine in complex with a 6-bp DNA
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs.
liq. N2 cooled Si-111 double monochromator
MPD, sodium cacodylate, cobalt hexammine, sodium chloride, potassium chloride, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
ANTICANCER, DNA BINDING, DRUG DESIGN, ELLIPTICINE, INTERCALATOR, DNA