Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAVKQALREAGDEFELRYRRAFSDLTSQLHITP GTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG NNAAAESRKGQERLEHHHHHH
solution structure of same protein, uncomplexed
crystal structure of same protein, uncomplexed
solution structure of same protein complexed with bak peptide
solution structure of same protein complexed with bad peptide
SEQUENCE RESIDUES 49-88 (SEQUENCE DATABASE RESIDUES 45-84) ARE NOT PRESENT DUE TO A LOOP DELETION.
1mM Bcl-xL U-15N,13C 50mM sodium phosphate, 5 mM deuterated Dithiothreitol, 100% D2O
AVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVS RIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER