Solution Structure of the Anti-apoptotic Protein Bcl-xL in Complex with "SAR by NMR" Ligands
4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAVKQALREAGDEFELRYRRAFSDLTSQLHITP GTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG NNAAAESRKGQERLEHHHHHH
Solution structure of same protein, uncomplexed.
Crystal structure of same protein, uncomplexed.
Solution structure of same protein complexed to Bak peptide
Solution structure of same protein complexed to Bad peptide
SEQUENCE RESIDUES 49-88 (SEQUENCE DATABASE RESIDUES 45-84) ARE NOT PRESENT DUE TO A LOOP DELETION.
1 mM Bcl-xL U-15N,13C; 50 mM sodium phosphate, 5 mM deuterated dithiothreitol, 100% D2O
AVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVS RIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQER