Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles

4-(1,3-BENZODIOXOL-5-YL)-5-(5-ETHYL-2,4-DIHYDROXYPHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

HSP 86, ATP binding domain of HSP90 alpha

MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNS
SDALDKIRYETLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIG
QFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQ
FIGYPITLFVEKERDKEVSDDEAE

PEG 6000, LiCl, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 9.00

cell-cycle, cancer, drug design, CELL CYCLE

DQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYETLTDPSKLDSGKELHINLIPNKQDRT
LTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGG
SFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAE