Dimeric parallel-stranded tetraplex with 3+1 5' G-tetrad interface, single-residue chain reversal loops and GAG triad in the context of A(GGGG) pentad
An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
A TETRAPLEX CONTAINING A GAG TRIAD IN THE CONTEXT OF AN A(GGGG)A DNA HEXAD
A TETRAPLEX CONTAINING A GAG TRIAD IN THE CONTEXT OF AN A(GGGG) DNA PENTAD
DNA aptamer obtained by SELEX of ODN inhibiting RNase H activity of HIV Reverse Transcriptase
The experiments 1H-15N HMBC, 1H-13C HMBC, 1H-13C HSQC, 1H-13C sHMBC were performed for assignments
all calculated structures submitted,back calculated data agree with experimental NOESY spectrum,structures with acceptable covalent geometry,structures with favorable non-bond energy
the structures are based on a total of 1689 restraints, 283 are NOE-derived distance constraints, 3 negative restraints, 84 dihedral angle restraints,104 distance restraints from hydrogen bonds, 243 intensity restraints (each of five mixing times)
distance geometry; simulated annealing; molecular dynamics; matrix relaxation
DIMERIC PARALLEL-STRANDED QUADRUPLEX; DNA APTAMER;HIV-1 INTEGRASE INHIBITOR DESIGN; 3+1 G-TETRAD; SINGLE NUCLEOTIDE CHAIN REVERSAL LOOP; GAG TRIAD; (A)GGGG PENTAD, DNA