Solution structure of human survivin and its binding interface with smac/diablo
Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKH SSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKET
This structure was determined using standard 3D NMR techniques
Structures were calculated using 1394 intra-monomer NOE constraints, thirty hydrogen bond restraints derived from an analysis of amide exchange rates and fifty-six torsional restraints from an analysis of the backbone chemical shifts. Dimer structures were calculated using additional inter-monomer NOE constraints.