Structure of Fab DNA-1 complexed with dT3

Evidence for Structural Plasticity of Heavy Chain Complementarity-determining Region 3 in Antibody-ssDNA Recognition

anti-single-stranded dna antigen-binding fab

ELQMTQSPASLSASVGETVTITCRASENIYSYLAWYQQKQGKSPQLLVYNAKTLAEGVPSRFSGSGSGTQFSLKINSLQP
EDFGSYYCQHHYGTPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL
NSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

QVKLLESGPELVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYINPYNDGTKYNEKFKGKATLTSDKSSSTAY
MELSSLTSEDSAVYYCVRGGYRPYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVT
WNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCTSHHHHHH

ammonium sulfate, sodium phosphate, sodium citrate, pH 5.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K

Structure of ligand-free Fab DNA-1 in space group P65

Structure of ligand-free Fab DNA-1 in space group P321 solved from crystals with perfect hemihedral twinning

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

The biological assembly is Fab, which has one light chain and one heavy chain

antibody, Fab, immunoglobulin, anti-DNA, anti-ssDNA, autoantibody, IMMUNE SYSTEM-DNA COMPLEX

LESGPELVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYINPYNDGTKYNEKFKGKATLTSDKSSSTAYMELS
SLTSEDSAVYYCVRGGYRPYYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSG
SLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCTS