Solution Structure of the SMRT Deacetylase Activation Domain
Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors
Deacetylase Activation Domain (residues 410-480)
SMRT, N-CoR2, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRTe, Thyroid-, retinoic-acid-receptor-associated corepressor, T3 receptor- associating factor, TRAC, CTG repeat protein 26, SMAP270
This structure was determined using a combination of standard 2D homonuclear techniques and 3D 15N TOCSY-HSQC and 15N NOESY-HSQC
1-2mM DAD, 50mM NaCl, 50mM phosphate buffer NA
1-2mM DAD U-15N, 50mM NaCl, 50mM phosphate buffer NA
Frank Delaglio Stephan Grzesiek, Guang Zhu, Geerten W. Vuister, John Pfeifer, Ad Bax
four-helix structure, three-helix triangle, TRANSCRIPTION COREPRESSOR