Human death-associated kinase DRP-1, mutant S308D d40

Structure of the inhibited conformation of DRP-1 kinase

DAP kinase 2, DAP- kinase related protein 1, DRP-1

GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITL
HDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKL
IDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE
FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLDFSIVSLCNHLT
R

PEG, sodium acetate, pH 7.4, VAPOR DIFFUSION, SITTING DROP, temperature 295K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. GROUP B FACTOR REFINEMENT IN CNS, OVERALL B FACTOR REFINEMENT IN REFMAC5
GROUP B FACTOR REFINEMENT IN CNS, OVERALL B FACTOR REFINEMENT IN REFMAC5

protein kinase, autoinhibitory helix, TRANSFERASE

MEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLH
DVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLI
DFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF
FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTR