NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2'-MONOPHOSPHOADENOSINE 5'-DIPHOSPHORIBOSE

Structure and Reactivity of Human Mitochondrial 2,4-Dienoyl-Coa Reductase: Enzyme-Ligand Interactions in a Distinctive Short-Chain Reductase Active Site

COFACTOR (N) NADP SUBSTRATE (S) 2,4-HEXADIENOYL-COA
2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR

2,4-DIENOYL-COA REDUCTASE [NADPH], 4-ENOYL-COA REDUCTASE [NADPH]

MNTEALQSKFFSPLQKAMLPPNSFQGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHA
IQCDVRDPDMVQNTVSELIKVAGHPNIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFL
SITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTGTFEKEMIGRIPCGRLGT
VEELANLAAFLCSDYASWINGAVIKFDGGEEVLISGEFNDLRKVTKEQWDTIEELIRKTKGS

BINARY STRUCTURE OF HUMAN DECR SOLVED BY SEMET SAD.

CATALYTIC ACTIVITY: TRANS-2,3-DIDEHYDROACYL-COA + NADP(+)= TRANS,TRANS-2,3,4,5-TETRADEHYDROACYL-COA + NADPH.

2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (E.C.1.3.1.34)

DIENOYL COA-REDUCTASE, SHORT CHAIN DEHYDROGENASE, BETA-OXIDATION, NADP, OXIDOREDUCTASE, REDUCTASE