The solution structure of the FATC Domain of the Protein Kinase TOR1 from yeast
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.
DISULFIDE BOND BETWEEN RESIDUES C2460 (23) AND C2467 (30)
PI3-KINASE RELATED, PTDINS-3-KINASE RELATED, PI3K RELATED
PHOSPHATIDYLINOSITOL 3-KINASE HOMOLOG REQUIRED FOR G1 PROGRESSION. TARGET OF THE ANTIBIOTIC RAPAMYCIN.
THE STRUCTURE WAS DETERMINED USING MULTINUCLEAR NMR EXPERIMENTS ON 15- OR 15N-13C-LABELED YEAST TOR1 FATC.
LOWEST ENERGY AND LEAST RESTRAINED VIOLATION
SHIFTS HAVE BEEN DEPOSITED AT BMRB UNDER ACCESSION NUMBER 6228
RESTRAINED TORSION ANGLE MOLECULAR DYNAMICS
PHOSPHATIDYLINOSITOL 3-KINASE TOR1 (E.C.2.7.1.137)
TOR, TARGET OF RAPAMYCIN, SER/THR KINASE, REDOX-REGULATION, DISULFIDE BOND, TRANSFERASE