Crystal structure of SARS Coronavirus Main Proteinase (3CLpro)

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH
SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQCSGVTFQ

PEG 6000, MES, DMSO, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K

The second part of the biological assembly is generated by the two fold axis

anti-parallel b-barrel, anti-parallel a-helices, Hydrolase