Crystal structure of human uridine-cytidine kinase 2 complexed with a feedback-inhibitor, UTP

Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase

Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2

rotated-inclined monochromator and vertical focusing mirror

PGMAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALK
GQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTD
ADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQT
NGCLNGYTPSRK

sodium tartrate, HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K

The same protein complexed with a substrate, cytidine.

ALPHA/BETA MONONUCLEOTIDE-BINDING HOLD, transferase

MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQ
FNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDAD
TRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINLIVQHIQDILNGGPSKRQTNG
CLNGYTPSRK