Crystal Structure of Estrogen Receptor beta complexed with WAY-338

Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.

DALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLM
MGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL
R

PEG3350, Mg formate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 291K

This sequence of this peptide can be found naturally in HOMO sapiens (human).

Estrogen Receptor, Estrogen Receptor Beta, ER-beta, ER, Estrogen, Nuclear Receptor, Transcription Factor, Agonist, TRANSCRIPTION