Peptidoglycan amidase MepA is a LAS metallopeptidase

Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases

Penicillin-insensitive murein endopeptidase

D-alanyl-D-alanine-endopeptidase, DD-endopeptidase

ATPWQKITQPVPGSAQSIGSFSNGCIVGADTLPIQSEHYQVMRTDQRRYFGHPDLVMFIQRLSSQVSNLGMGTVLIGDMG
MPAGGRFNGGHASHQTGLDVDIFLQLPKTRWTSAQLLRPQALDLVSRDGKHVVSTLWKPEIFSLIKLAAQDKDVTRIFVN
PAIKQQLCLDAGTDRDWLRKVRPWFQHRAHMHVRLRCPADSLECEDQPLPPSGDGCGAELQSWFEPPKPGTTKPEKKTPP
PLPPSCQALLDEHVI

ammonium sulfate, MES, PEG monomethyl ether 5000, 1,4-butanediol, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K

A partial model of MEPA in a different crystal form

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Dimer in three different crystal forms.lution not characterized

LAS enzyme, metallopeptidase, peptidoglycan hydrolase, Hydrolase