SOLUTION STRUCTURE OF A LINKED UNSYMMETRIC GRAMICIDIN IN A MEMBRANE-ISOELECTRICAL SOLVENTS MIXTURE IN THE PRESENCE OF CsCl
An Asymmetric Ion Channel Derived from Gramicidin A. Synthesis, Function and NMR Structure.
High-Resolution Conformation of Gramicidin a in a Lipid Bilayer by Solid-State NMR
Solution Structure of a Parallel Left-Handed Double-Helical Gramicidin-A Determined by 2D 1H NMR
Cation Control in Functional Helical Programming: Structures of a D,L-Peptide Ion Channel
CRYSTAL STRUCTURE OF GRAMICIDIN S COMPLEXED WITH ALKALINE PROTEINASE SAVINASE
CRYSTAL STRUCTURE OF GRAMICIDIN A FROM CRYSTALS GROWN IN A LIPID CUBIC PHASE.
CRYSTAL STRUCTURE OF GRAMICIDIN A COMPLEXED WITH CESIUM CHLORIDE
CRYSTAL STRUCTURE OF GRAMICIDIN A FROM BACILLUS BREVIS
CRYSTAL STRUCTURE OF GRAMICIDIN A COMPLRXED WITH POTASSIUM THIOCYANATE
SOLUTION STRUCTURE OF GRAMICIDIN A IN SODIUM DODECYL SULFATE MICELLES
SOLUTION STRUCTURE OF A LINKED SHORTENED GRAMICIDIN A IN BENZENE/ACETONE 10:1
SOLID STATE NMR STRUCTURE OF GRAMICIDIN A IN HYDRATED DMPC BILAYERS,
SOLUTION STRUCTURE OF GRAMICIDIN A IN METHANOL IN THE PRESENCE OF CACL
SOLUTION STRUCTURE OF GRAMICIDIN A (W15G) IN SODIUM DODECYL SULFATE MICELLES
SOLUTION STRUCTURE OF GRAMICIDIN A IN DODECYL PHOSPHOCHOLINE MICELLES
SOLUTION STRUCTURE OF GRAMICIDIN A IN DODECYL PHOSPHOCHOLINE MICELLES IN THE PRESENCE OF EXCESS NA+
SOLUTION STRUCTURE OF GRAMICIDIN A (V1F) IN SODIUM DODECYL SULFATE MICELLES
SOLUTION STRUCTURE OF GRAMICIDIN B IN SODIUM DODECYL SULFATE MICELLES
SOLUTION STRUCTURE OF GRAMICIDIN C IN SODIUM DODECYL SULFATE MICELLES
SOLUTION STRUCTURE OF F1-GRAMICIDIN C IN SODIUM DODECYL SULFATE MICELLES
CRYSTAL STRUCTURE OF GRAMICIDIN D IN ETHANOL
CRYSTAL STRUCTURE OF GRAMICIDIN D COMPLEX WITH KI IN METHANOL
CRYSTAL STRUCTURE OF GRAMICIDIN D COMPLEX WITH NAI
CRYSTAL STRUCTURE OF GRAMICIDIN D IN N-PROPANOL
CRYSTAL STRUCTURE OF GRAMICIDIN D IN METHANOL
GRAMICIDIN IS A HETEROGENEOUS MIXTURE OF SEVERAL COMPOUNDS INCLUDING GRAMICIDIN A, B AND C WHICH ARE OBTAINED FROM BACILLUS BREVIS AND CALLED COLLECTIVELY GRAMICIDIN D HERE, MODIFIDED GRAMICIDIN A IS REPRESENTED BY TWO SEQUENCES (SEQRES AND ONE HET (SIN)
BOTH OF THE C-TERMINI HAVE ETHANOLAMINE ATTACHED WITH THE CAPPING GROUP T-BUTYLDIPHENYLSILYL, WHICH WAS APPLIED TO ENHANCE THE SOLUBILITY AND STABILITY OF THE STRUCTURE IN ORGANIC SOLVENTS. OWING TO AMBIGUITY IN RESONANCE ASSIGNMENT OF THE TERMINI AND THEREFORE A LACK OF ENOUGH NOE CONSTRAINTS, THE T-BUTYLDIPHENYLSILYL TERMINI WERE OMITTED IN THE STRUCTURE CALCULATION.
THE N-TERMINI OF THE TWO PEPTIDES, EACH A TRUNCATED GRAMICIDIN A, WERE LINKED BY A SUCCINIC ACID IN A HEAD-TO-HEAD MANNER.
VARIABLE TEMPERATURE EXPERIMENTS WERE PERFORMED TO HAVE THE TEMPERATURE DEPENDENCE OF NH CHEMICAL SHIFTS, THEREFORE PROVIDE EVIDENCE FOR HYDROGEN BONDING.
MINIMIZED AVERAGE STRUCTURE OF 11 STRUCTURES WITH THE LOWEST TARGET FUNCTION
THE STRUCTURES ARE BASED ON 160 NOE- DERIVED DISTANCE CONSTRAINTS, 39 DIHEDRAL ANGLE RESTRAINTS, AND 40 DISTANCE RESTRAINTS FROM HYDROGEN BONDS
GRAMICIDIN, ANTIFUNGAL, ANTIBACTERIAL, ANTIBIOTIC, MEMBRANE ION CHANNEL, LINEAR GRAMICIDIN