NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
Baculoviral IAP repeat-containing protein 4
Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQ HAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
Another Antagonist/Bir3 complex structure
3D_13C,15N filtered ,13C separated NOESY
COMPLEX, ligand-PROTEIN, APOPTOSIS, BIR, XIAP
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT