NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
Baculoviral IAP repeat-containing protein 4
Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, XIAP, X-linked IAP, IAP-like protein, HILP
MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQ HAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
3D_13C,15N filtered ,13C separated NOESY
U-15N, 0.8mM Bir3,20mM Tris, 2mMDTT, 20mM phosphate buffer, 120mM NaCl, 90%H2O, 10%D20
U-15N,13C 0.8mM Bir3, 20mM Tris, 2mMDTT, 20mM phosphate buffer, 120mM NaCl, 100%D2O
COMPLEX, ligand-PROTEIN, APOPTOSIS, BIR, XIAP
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQH AKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT