Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3

Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation

beta-catenin-interacting protein ICAT; Inhibitor of beta-catenin and Tcf-4

AELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR
EGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILA
YGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTL
RNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAI
CALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQ
DTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDK
EAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSE

PEG3400, Potassium phosphate, pH 6.5, EVAPORATION, temperature 297K

beta-catenin; Wnt signal; APC; 20mer repeat; Wnt signaling, cell adhesion-cell cycle COMPLEX