Crystal structure of a Statin bound to class II HMG-CoA reductase

(3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID

Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.

3-hydroxy-3-methylglutaryl-coenzyme A reductase

MSLDSRLPAFRNLSPAARLDHIGQLLGLSHDDVSLLANAGALPMDIANGMIENVIGTFELPYAVASNFQINGRDVLVPLV
VEEPSIVAAASYMAKLARANGGFTTSSSAPLMHAQVQIVGIQDPLNARLSLLRRKDEIIELANRKDQLLNSLGGGCRDIE
VHTFADTPRGPMLVAHLIVDVRDAMGANTVNTMAEAVAPLMEAITGGQVRLRILSNLADLRLARAQVRITPQQLETAEFS
GEAVIEGILDAYAFAAVDPYRAATHNKGIMNGIDPLIVATGNDWRAVEAGAHAYACRSGHYGSLTTWEKDNNGHLVGTLE
MPMPVGLVGGATKTHPLAQLSLRILGVKTAQALAEIAVAVGLAQNLGAMRALATEGIQRGHMALHARNIAVVAGARGDEV
DWVARQLVEYHDVRADRAVALLKQKRGQ

pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 293K

Ternary Complex Of Pseudomonas Mevalonii Hmg-Coa Reductase With Hmg-Coa and Nad+

Ternary Complex Of Pseudomonas Mevalonii Hmg-Coa Reductase With Mevalonate and Nad+

Hmg-Coa Reductase From Pseudomonas Mevalonii Complexed With Hmg-Coa

Hmg-Coa Reductase From P. Mevalonii, Native Structure At 2.2 Angstroms Resolution

Statin, HMG-CoA reductase, complex, OXIDOREDUCTASE