Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)

Structural basis of protein phosphatase 1 regulation

Serine/threonine protein phosphatase PP1-beta (or delta) catalytic subunit
additional AGH residues at the N-terminus

130 kDa myosin-binding subunit of smooth muscle myosin phophatase (M130)

AGHMADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEY
GGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNC
LPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNR
HDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTP
PRTANPPKKR

MKMADAKQKRNEQLKRWIGSETDLEPPVVKRKKTKVKFDDGAVFLAACSSGDTEEVLRLLERGADINYANVDGLTALHQA
CIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEYLISQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVN
RQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQARYDVNIKDYDGWTPLHAAA
HWGKEEACRILVENLCDMEAVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKREKKS

PEG 5000 monomethylether, glycerol, NH4Cl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K

PROTEIN SER/THR PHOSPHATASE-1 (ALPHA) COMPLEXED WITH MICROCYSTIN-LR TOXIN

PROTEIN SER/THR PHOSPHATASE-1 (GAMMA) COMPLEXED WITH CALICULIN A

PROTEIN SER/THR PHOSPHATASE-1 (GAMMA) COMPLEXED WITH THE TUMOR-PROMOTER OKADAIC ACID

1FJM for molecule 1 and 3 ankyrin repeats from 1IHB for molecule 2

myosin phosphatase, MYPT1, PP1, myosin regulation, deposphorylation, HYDROLASE

MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGF
PPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPI
AAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRT
ANPPKKR