Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus.
SEQUENCE The peptide was N-terminally acetylated and C-terminally amidated, the coordinates do not reflect these modifications
This structure was determined using standard 2D homonuclear techniques
10mM deuterated imidazole, 4mM ZnSO4, 1mM deuterated DTT,
1.2 to 3.0mM peptide, 10mM deuterated imidazole, 4mM ZnSO4, 1mM deuterated DTT, at pH 6.0, 90% H2O, 10% D2O
1.2 to 3.0mM peptide, 10mM deuterated imidazole, 4mM ZnSO4, 1mM deuterated DTT, at pH 6.0, 99.96% D2O
E6-binding domain, zinc finger, human papillomavirus, HPV E6 protein, DE NOVO PROTEIN