CRYSTAL STRUCTURE OF A FLUORESCENT DERIVATIVE OF RNASE A
Fluorescent Probe of Ribonuclease A Conformation
ETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSI TDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV
THE FLUORESCENT LABEL AEDANS, THREE CHLORIDE ANIONS AND 103 WATER MOLECULES WERE ADDED TO THE MODEL.
REFINEMENT WAS STARTED FROM THE ISOMORPHOUS STRUCTURE OF THE SEMISYNTHETIC (1-118:111-124(D121A)).
RIBONUCLEASE A (E.C.3.1.27.5) FLUORESCENT DERIVATIVE [RNASE 1-124 (AENS-HIS -12)] FROM NACL CRYSTAL
MALKSLVLLSLLVLVLLLVRVQPSLGKETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADV QAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV