Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T-cell activation

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.

H-2 class II histocompatibility antigen, E-K alpha chain

EEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPD
ANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYD
CEVDHWGLEEPLRKHWEFEE

APWFLEYSKSECHFYNGTQRVRLLVRYFYNLEENLRFDSDVGEFRAVTELGRPDAENWNSQPEFLEQKRAEVDTVCRHNY
EIFDNFLVPRRVEPTVTVYPTKTQPLEHHNLLVCSVSDFYPGNIEVRWFRNGKEEKTGIVSTGLVRNGDWTFQTLVMLET
VPQSGEVYTCQVEHPSLTDPVTVEW

PEG, pH 7, VAPOR DIFFUSION, SITTING DROP, temperature 298K

TCR, MHC class II, structural rearangement, SIGNALING PROTEIN