THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
SECOND EXTRACELLULAR IMMUNOGLOBULIN-LIKE DOMAIN
SDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCE ATVNGHLYKTNYLTHRQTNTI
MODIFIED QIAGEN PQE30 CONTAINING HIS-TAG AND GENENASE CLEAVAGE SITE
1.7 A RESOLUTION CRYSTAL STRUCTURE OF THE SECOND IMMUNOGLOBULIN DOMAIN OF FLT- 1 IN COMPLEX WITH VEGF
1QSZ contains the minimized mean structure for the ensemble of structures in 1QSV.
AN ADDITIONAL SAMPLE THAT WAS 15% 13C LABELED WAS USED TO OBTAIN STEREOSPECIFIC ASSIGNMENTS OF PROCHIRAL METHYL GROUPS.
STRUCTURES WITH ACCEPTABLE COVALENT GEOMETRY,STRUCTURES WITH THE LEAST RESTRAINT VIOLATIONS
THE STRUCTURES ARE BASED ON A TOTAL OF 2054 NOE-DERIVED DISTANCE RESTRAINTS, 122 DIHEDRAL RESTRAINTS, AND 44 DISTANCE RESTRAINTS FROM HYDROGEN BONDS.
DISTANCE GEOMETRY/SIMULATED ANNEALING; MOLECULAR DYNAMICS
closest to the average,fewest violations
1MM FLT-1(DOMAIN2) U-15N,13C; PHOSPHATE BUFFERED SALINE, PH 5.7; 50UM EDTA; 100UM NAN3; 50UM DSS
1MM FLT-1(DOMAIN2) U-15N; PHOSPHATE BUFFERED SALINE, PH 5.7; 50UM EDTA; 100UM NAN3; 50UM DSS
IMMUNOGLOBULIN-LIKE DOMAIN, I-SET, VEGF RECEPTOR, HORMONE-GROWTH FACTOR RECEPTOR COMPLEX