HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVF
EFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYT
HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

PEG 6000, NA-HEPES, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K

Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Staurosporine

Human Cyclin-Dependent Kinase 2 Phosphorylated On Thr 160

Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor Purvalanol B

The Structure Of Cyclin-Dependent Kinase 2 (Cdk2) In Complex With 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline

Human Cyclin-Dependent Kinase 2 Complexed With The Inhibitor Hymenialdisine

Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor 2058

Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor 6027

Thr 160 Phosphorylated Cdk2 - Human Cyclin A3 Complex With The Inhibitor Indirubin-5-Sulphonate Bound

Cyclin A - Cyclin-Dependent Kinase 2 Complex

The Structure Of Cyclin-Dependent Kinase 2 (Cdk2) In Complex With An Oxindole Inhibitor

The Structure Of Cdk2/Cyclin A In Complex With An Oxindole Inhibitor

Crystal Structure Of Human Cyclin Dependent Kinase 2 (Cdk2) In Complex With The Inhibitor H717

Human Cyclin Dependent Kinase 2 Complexed With The Cdk4 Inhibitor

Human Cyclin Dependent Kinase 2 Complexed With The Inhibitor 2-Amino-6-(3'-Methyl-2'-Oxo)Butoxypurine

The Structure Of Cyclin-Dependent Kinase 2 (Cdk2) In Complex With 4-[(6-Amino-4-Pyrimidinyl) Amino]Benzenesulfonamide

Crystal Structure Of Human Cdk2 (Unphosphorylated) In Complex With Pkf049-365

Cdk2 Complexed With N-Methyl-4-{[(2-Oxo-1,2-Dihydro-3H- Indol-3-Ylidene)Methyl]Amino}Benzenesulfonamide

Cyclin-Dependent Kinase 2 (Cdk2) Complexed With N-Methyl-{4-[2-(7-Oxo-6,7-Dihydro-8H-[1,3]Thiazolo[5,4-E]Indol-8-Ylidene)Hydrazino]Phenyl}Methanesulfonamide

Cyclin-Dependent Kinase 2 (Cdk2) Complexed With 3-{[(2,2-Dioxido-1,3-Dihydro-2-Benzothien-5-Yl)Amino]Methylene}-5-(1,3-Oxazol-5-Yl)-1,3-Dihydro-2H-Indol-2-One

Cyclin-Dependent Kinase 2 (Cdk2) Complexed With 4-{[(2-Oxo-1,2-Dihydro-3H-Indol-3-Ylidene)Methyl]Amino}-N-(1,3-Thiazol-2-Yl)Benzenesulfonamide

Cyclin-Dependent Kinase 2 (Cdk2) Complexed With 3-{[4-({[Amino(Imino)Methyl]Aminosulfonyl)Anilino]Methylene}-2-Oxo-2,3-Dihydro-1H-Indole

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR [4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine

HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR N-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-N',N'-dimethyl-benzene-1,4-diamine

HETEROGEN
CK5 500 has alternate conformation with HOH 501,502,503,504,505,506,507,508,and 509.

PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, ATP-BINDING, 3D-STRUCTURE.