CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH ACYCLOVIR

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir.

Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

ENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYSEIPNFPRSTVPGHAGRLVFGFLNGRACVMM
QGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPA
MSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLI
TNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS

17.5% AMMONIUM SULFATE, pH 5.30, VAPOR DIFFUSION, HANGING DROP, temperature 293K

CRYSTAL STRUCTURE OF HUMAN PNP AT 2.3A RESOLUTION

CRYSTAL STRUCTURE OF HUMAN PNP COMPLEXED WITH IMMUCILLIN H

THE BIOLOGICAL ASSEMBLY IS A TRIMER GENERATED FROM THE MONOMER IN THE ASYMMETRIC UNIT

PURINE NUCLEOSIDE PHOSPHORYLASE, DRUG DESIGN, SYNCHROTRON, ACYCLOVIR, TRANSFERASE