POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION

(METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE

Ligand-induced conformational changes in poliovirus-antiviral drug complexes.

Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14

Structures of Poliovirus Complexes with Anti-Viral Drugs: Implications for Viral Stability and Drug Design

Washington, Dc : American Society for Microbiology
New Aspects of Positive-Strand RNA Viruses
Role of Conformational Transitions in Poliovirus Assembly and Cell Entry

Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus

Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1

GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESF
FARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYV
PPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGIL
AVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY

SPNIEACGYSDRVLQLTLGNSTITTQEAANSVVAYGRWPEYLRDSEANPVDQPTEPDVAACRFYTLDTVSWTKESRGWWW
KLPDALRDMGLFGQNMYYHYLGRSGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSNTTTMHTSYQNANPGEKGGTFTGT
FTPDNNQTSPARRFCPVDYLLGNGTLLGNAFVFPHQIINLRTNNCATLVLPYVNSLSIDSMVKHNNWGIAILPLAPLNFA
SESSPEIPITLTIAPMCCEFNGLRNITLPRLQ

GLPVMNTPGSNQYLTADNFQSPCALPEFDVTPPIDIPGEVKNMMELAEIDTMIPFDLSATKKNTMEMYRVRLSDKPHTDD
PILCLSLSPASDPRLSHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGADPPKKRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTIDDSFTEGGYISVFYQTRIVVPLSTPREMDILGFVSACNDFSVRLLRDTTHIEQKALAQ

P1/MAHONEY PREPARED FROM A LOW-PASSAGE STOCK, PROVIDED BY MARIE CHOW, OF A PLAQUE ISOLATED FROM HELA CELLS TRANSFECTED WITH AN INFECTIOUS CDNA CLONE OF THE VIRAL GENOME. THE ANTIVIRAL COMPOUND R80633 WAS DEVELOPED BY JANSSEN PHARMACEUTICA.

Coordinates and associated matrices have been transformed from the icosahedral point symmetry frame to the crystallographic frame

REFINED STRUCTURE OF P1/MAHONEY (2PLV), AFTER OMITTING ALL LIGANDS, SOLVENT, AND ANY AMINO ACID LOCATED CLOSE TO A SIGNIFICANT ELECTRON DENSITY FEATURE IN THE NON-CRYSTALLOGRAPHIC SYMMETRY-AVERAGED DIFFERENCE MAP.

icosahedral asymmetric unit, std point frame

POLIOVIRUS, PICORNAVIRUS COAT PROTEIN, ANTI-VIRAL DRUGS, HYDROLASE, THIOL PROTEASE, Icosahedral virus, Virus