Crystal Structure of the EF3-CaM complexed with PMEApp

9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE DIPHOSPHATE

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

ATP pyrophosphate-lyase, Adenylyl cyclase, Edema factor, EF, Anthrax edema toxin adenylate cyclase component

RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLS
KKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENN
EVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTN
LLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMT
GRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKK
ESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNI
EFKLLYKQLNFTENETDNFEVFQKIID

ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTD
SEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTA

PEG 8000,ammonium sulfate, glycerol, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 273K

crystal structure of EF3-CaM complexed with 2'd3'ANT-ATP

edema factor, CaM, prodrug complex, lyase-metal binding protein COMPLEX