SOLUTION STRUCTURE OF TOXIN CN12 FROM CENTRUROIDES NOXIUS ALFA SCORPION TOXIN ACTING ON SODIUM CHANNELS. NMR STRUCTURE
NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
TOXIN OBTAINED DIRECTLY FROM VENOM OF CENTRUROIDES NOXIUS. ACTIVITY IS VERY LOW, HOWEVER CN12 HAS SOME REQUIREMENTS FOR BEING A VERY ACTIVE TOXIN.
SAME SECONDARY STRUCTURE AS NA+ CHANNEL TOXINS.
SEQUENCE At the time of processing, no reference database sequence for this protein was available.
THE STRUCTURE WAS DETERMINED USING HOMONUCLEAR 1H-1H 2D NMR ON THE NATURAL TOXIN EXTRACTED FROM THE SCORPION VENOM
NO RESTRAINT VIOLATIONS LESS THAN 0.2 ANGSTROMS AND MIMINUM ENERGY LESS THAN 115.0 KCAL/MOL BEST REPRESENTATIVE CONFORMER IN THIS ENSEMBLE: 1
TOXIN, SCORPION TOXIN, CENTRUROIDES NOXIUS, SODIUM CHANNELS ALPHA TOXIN